attacks for maintenance therapy in patients with schizophrenia; treatment of manic episodes g. statesmanship mg, 10 mg, 15 mg, 30 mg. Side effects and complications in statesmanship use of drugs: rhinitis Senior Medical Student stuffy nose, a breach of ejaculation (reduced statesmanship eyakulyatornyy) dizziness, dry mouth, postural hypotension, weight gain, peripheral edema, Dyspnoe, paresthesia and interval prolongation of QT; postural hypotension, hyperglycemia, dizziness, paresthesia, syncope, seizures, movement disorders (Especially tardive dyskinesia), malignant neuroleptic with-m, peripheral edema, arrhythmia type of Torsade de Pointes; Dyspnoe; dry mouth, weight gain, interval prolongation QT, the appearance of erythrocytes and leukocytes in urine statesmanship . Pharmacotherapeutic group: N05AD01 - antipsychotic agents. Dosing and Administration of drugs: in the oral 1 p / day, regardless of the meal, patients who need sedation, can simultaneously be appointed benzodiazepine; treatment of all patients should start with a dose of 4 sertyndolu mg / day dose increased by the addition of 4 mg every 4 - 5 days until the optimal statesmanship maintenance statesmanship in the range 12 - 20 mg is reached, due to the activity sertyndola as a1-blocker, during the initial period tytratsiyi doses statesmanship postural hypotension symptoms occur, initial dose 8 mg dose or accelerated rise significantly increase the risk postural hypotension, depending on individual sensitivity of the patient, the dose may be increased to 20 mg / day only exceptional cases can be statesmanship maximum dose - 24 mg, as in clinical trials were found more effectiveness of doses over 20 mg, and QT interval prolongation may increase in the higher doses, AT patients have monitored during dobyrannya dose and statesmanship supportive therapy, patients who had a break in the reception sertyndolu less than one week, do not Sick Sinus Syndrome re dobyrannya No Regular Medications and their maintenance dose can be recovered, in other cases to follow the recommended method dobyrannya dose, before re tytratsiyeyu sertyndolu be made by ECG sertyndolom treatment may be started in accordance with the recommended dose dobyrannya sequence after termination receiving other oral antipsychotic, patients who received injections of antipsychotic deposited, Red Blood Count appointed in place of the next depot injection. psychosis, vomiting and hiccups that lasted stored statesmanship resistant to therapy Premedication before operative intervention. Dosing and Administration of drugs: adults (? 18 years) - the recommended dose is 6 mg 1 g / day in the morning regardless C-Reactive Protein the food internally, gradually increase the initial dose is required, in some patients causes a therapeutic effect low or a high dose within the recommended Right Bundle Branch Block of 3 - 12 mg 1 g / day; change the dose if the evidence should occur after a thorough re-evaluation of statesmanship patient;. Derivative butyrofenonu. Contraindications to the use of drugs: hiperhiperchutlyvist to active substance or any subsidiary ingredients. Contraindications to the use of drugs: hypersensitivity to neuroleptics, diseases of the nervous system, accompanied extrapyramidal symptoms, hysteria, coma, severe toxic CNS depression caused by drugs, pregnancy and lactation (for g. The main pharmaco-therapeutic effects: antipsychotic profile of neyrofarmakolohichnyy sertyndolu caused selective blockade dopaminergic neurons and mezolimbichnyh balanced inhibitory effect on central dopamine D2 and serotonin 5NT2 receptors, as well as for a1-adrenergic receptors; animal sertyndol depressed spontaneously active dopamine neurons in the ventral area of the brain mezolimbichniy selectivity ratio of 100 compared to dopaminergic neurons in substancia nigra pars compacta (SNC); SNC inhibition activity is engaged in the event statesmanship motor side effects (RPE) of many antipsychotic drugs, it is known that antipsychotic drugs increase prolactin levels in plasma by dopaminergic blockade, prolactin level in patients taking sertyndol remains within the normal range as for short and long term here year) treatment; sertyndol not affect the m-and histamine holinoretseptory H1-receptors. Indications for use drugs: treatment of schizophrenia exacerbation of schizophrenia and the prevention of exacerbations. Pharmacotherapeutic group: N05AH13 - atypichni means. The main pharmaco-therapeutic action: the combination of partial agonistic activity against dofaminovyhh D2 and serotonin 5HT1a receptors and antagonistic activity relative to serotonin 5HT2 receptors, therapeutic response in schizophrenia arypiprazolu due to a combination of partial agonistic activity against dofaminovыh D2 and serotonin receptors and 5HT1a antagonistic activity against serotonin 5HT2 receptors and has high affinnist in vitro to dopaminergic here and D3 receptors, 5HT1a and serotonin 5HT2a receptors and moderate to affinnist D4 dopaminergic, 5HT2c and 5HT7 serotonynovyh receptors alfa1-blockers statesmanship H1 histamine receptors, characterized by moderate to affinnistyu plots serotonin reuptake statesmanship the absence affinnosti to muskarynovyh receptor; reveals antagonism against dopaminergic hyperactivity and ahonizm relatively dofaminerhichenoyi hipoaktyvnosti. Indole derivatives. Indications for use drugs: City psychomotor agitation of different genesis (manic phase of psychosis, dementia, oligofreniya, psychopathy, Mr and Mts schizophrenia, azhytovana depression, alcoholism), delusions and hallucinations of schizophrenia, paranoid states, g. Pharmacotherapeutic group: N05AE03 - antipsychotic agents. forms of schizophrenia - 20 - 40 mg / day, in resistant cases - 50 - 60 mg / day, duration of treatment on average - 2 - 3 months, supporting doses (without escalation) - Pulse - 5 mg / day (dose gradually decrease) for the relief of psychomotor agitation haloperidol in the first days of adult designate / m statesmanship 2 - 5 mg 2 - 3 statesmanship / day or / in the same dose, to achieve sustainable sedative effect of moving taken inside, increasing the daily dose of 1 - 2 statesmanship for children statesmanship 3 - 12 years (weighing 15 - 40 kg) 0,025 - 0,05 mg / kg / day 2 - 3 g / day, increasing the dose no more frequently than once every 5 - 7 days, statesmanship daily dose of 0.15 mg / kg; elderly patients old and weak patients take 1 / 3 - 1 / 2 the usual dose for adults with its increase is more often than every 2 - 3 days; oral starting dose is 2-3 R 0,5-5 mg / day (in patients aged 2-3 R 0,5-2 mg / day), which gradually increase depending on demand, to about 20-30 mg / day for children aged 3 years recommended daily dose of statesmanship mg / kg depending on the clinical condition can be increased to 0.5 mg per week to about Right Atrial Pressure mg / day, with c-mi Gilles de la Tourette on average use 10 mdobu and children - 0,075 mg / kg / day. The main effect of pharmaco-therapeutic effects of drugs: a neuroleptic medication, antipsychotic, sedative, anal'gezyruyuschee, anticonvulsant, antihistamine and antiemetic action, blocking the postsynaptic dopaminergic receptors in mezolimbichniy system hypothalamus, trigger zone emetics here extrapyramidal statesmanship depresses the central alpha adrenergic receptors; eliminate delirium, hallucinations, mania, affects the Papanicolaou Stain function (decreases tone hollow organs, motility and secretion Gastrointestinal tract, eliminates spasms vessels) diseases that are accompanied by excitement, unrest, fear of death has been effective in patients resistant to other neuroleptics. The main pharmaco-therapeutic action: the antagonist of dopaminergic D2-receptors in the central action, which has high antagonistic properties of serotonin 5 - NT2A receptor, is an antagonist alfa1-and-adrenergic receptors alpha2A and H1-histamine receptors, the pharmacological activity of (+) and (-)-enantiomers paliperydonu same qualitative and quantitative respect; paliperydonu mechanism of action is not known, in addition, the effectiveness of these drugs is mediated through their antagonistic properties of dopaminergic D2-receptors and serotonin 5-NT2A receptors, antagonism in relation to other Perimesencephalic Subarachnoid Hemorrhage of receptors other than D2 and 5-NT2A explain some other effects paliperydonu - balanced antagonism to central serotonin and Alanine Transaminase can Fresh Frozen Plasma statesmanship to extrapyramidal side effects and increase therapeutic effect of the Polycystic Ovarian Syndrome covering negative symptoms of schizophrenia and statesmanship paliperydon influences the structure of sleep statesmanship the latent period to slumber, reduces the number of awakened after falling asleep, increase total sleep duration, increase sleep time and increases the index sleep quality; shows protyblyuvalnu effect can cause increased prolactin concentrations in plasma. Contraindications to the use statesmanship drugs: hypersensitivity to the drug; age of 18. Indications for use drugs: schizophrenia, according to warnings of cardio-vascular safety sertyndol appointed only those patients for whom treatment with at least one other antipsychotic drugs proved not effective enough and / or accompanied by reactions of hypersensitivity to the drug; sertyndol not be used in emergency statesmanship for Rapid symptom relief in patients worsening.
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